MOTS-C NAD+ Stack For Rehab Recovery Results

MOTS-C is a mitochondrial derived peptide, the mouse data shows AMPK activation and better insulin sensitivity, that part's solid in rodents. SS-31 binds cardiolipin and stabilizes the inner mitochondrial membrane, mostly studied in ischemia reperfusion models, not tendon recovery. NAD+ IV stuff is mostly subjective energy reports plus some small human trials in other contexts. None of that tells you your tendon heals faster, it tells you cellular energy production might be better supported while you're loading it.

Sleep did more for my recovery than any peptide stack ever has.

Feeling more energy isn't the same as faster tendon healing.

NAD+ helped my fatigue a ton during marathon buildup, no idea if it did anything for the Achilles itself honestly.

Fair, hard to isolate which variable is actually doing the work here.

SS-31 human data is still thin, mostly early phase stuff for heart and kidney conditions, nothing on tendons.

The distinction in your log is useful: better morning energy and faster tissue repair are different outcomes. tendon_tinker and AchillesAnna both describe improvements here, but also explain why they can't attribute tendon healing to the stack. Keeping that caveat with the positive report makes it more informative. One update to the SS-31 discussion: elamipretide now has an FDA-approved medicine, Forzinity, for muscle strength in people with Barth syndrome weighing at least 30 kg. That is a very specific population, not an approval for training recovery or this three-compound combination. The FDA's trial summary is particularly instructive: the 12-person randomized study did not show superiority to placebo on its walking-distance and fatigue endpoints. Knee-extension strength improvements appeared in the longer open-label extension, supporting accelerated approval with further confirmation required. Source: https://www.fda.gov/drugs/drug-trials-snapshots/drug-trials-snapshots-forzinity For interpreting a recovery log, I'd want the same outcome measured consistently, alongside training load, sleep and other changes. A lower resting heart rate or less soreness may be worth recording; neither directly measures tendon repair or isolates which compound did what. I contribute to PeptideWHY. Our evidence-reading guide explains how to separate a personal log, a controlled trial and a result in a different patient group: https://peptidewhy.com/research-method/ — useful when a stack discussion mixes all three.

That link dropping guy sounds like a brochure. I just track whether I can press overhead without it feeling like glass in the joint. MOTS-C hasn't moved that needle for me either way.

Overhead press glass feeling is such a specific sensation, I know exactly what you mean. For me it's more about whether I can hit the same interval numbers two days after a hard block without feeling wrecked. Still can't prove the stack is doing that versus just better sleep lately.