posted by rotator_cuff_rick 18d ago

Peptides around a tendon repair, timing questions for the clinician

Splitting this off my update thread because it is a distinct question and people keep asking me in replies. For anyone who has been through a surgical tendon repair and discussed peptides with a clinician: what were the timing considerations that actually came up? Not doses. Timing and reasoning. My own consult raised two things I had not thought about: that the early post op window has a specific biological job that you may not want to interfere with, and that anticoagulant use post surgery is a screening question.

Two years of patience beat six months of panic.

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PharmD_NadiaPhoenix, AZ8 points18d ago

Anticoagulation is the hard stop here. Post-op patients are frequently on blood thinners, which interacts directly with screening for these compounds. It is not just a form to check off. Skipping it to get an approval removes the only safety check in place. The rest of the timing is a prescriber call based on the specific procedure.

If the vial looks cloudy, the answer is no.

Dr_Rehab_RayCleveland, OH10 points18d ago

Surgeons usually point to the early inflammatory phase: it's doing essential work, and we lack data on whether altering that during the first few weeks is safe. Caution is the default for a reason. What matters most to me as a clinician is that the post-op protocol IS the intervention. Sling time, passive to active movement, and when you start loading are all set by tissue healing timelines. You shouldn't use anything as an excuse to push ahead of that schedule.

Load is the drug with the best data.

rotator_cuff_rickNaperville, IL6 points18d ago

That last line needs to be on a poster. The post-op temptation is to think you bought a shortcut. My PA called me out on that exact thing and she was right.

Two years of patience beat six months of panic.

slow_healer_samBoise, ID5 points17d ago

Did anyone's surgeon flatly say no rather than even entertain the conversation?

Still here. Still slow.

copper_curiousMiami, FL5 points17d ago

Mine did for a hand repair. He made it clear he didn't want an unknown variable in a small area with tight tolerances if something went wrong. I didn't love it, but his reasoning was solid so I didn't push back.

Collagen is a process, not a purchase.

LabRatLouisBoston, MA4 points16d ago

Unproven runs cut both ways. Nobody can guarantee a faster recovery, and a surgeon protecting a fresh repair is being completely rational. Lack of proof isn't a green light to pin.

Preclinical is not a promise.