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posted by LabRatLouis 10d ago

First US injectable BPC-157 RCT, anyone got details

Saw this pop up on reddit yesterday, first US based randomized controlled trial for injectable BPC-157 looking at tissue healing outcomes. No huge writeup yet just an announcement it exists. Given how much of what we cite in here is still rat and rabbit data this actually matters a lot if it's designed well. Anyone seen the trial registration itself, sample size, endpoints, anything more concrete than the headline.

Preclinical is not a promise.

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tendon_tinkerAustin, TX9 points10d ago
This is the thing I've wanted for four years. My whole spreadsheet is n=1 self report, would be nice to have an actual control arm to compare against instead of me guessing whether week 6 improvement was the peptide or just time and loading.

Measure it or it did not happen.

DrBauer_CLTCharlotte, NC9 points10d ago
Worth being clear about what this actually changes. A registered RCT means someone got IRB approval and is running it under an IND, which is a real step up from the animal literature we've all been leaning on. But even a well designed trial takes years, you've got enrollment, the actual run, then data analysis and publication, then whatever regulatory conversation follows if results are positive. It does not mean injectable BPC-157 becomes broadly prescribable or insurance covered anytime soon, and it does not undo where things currently stand with compounding access in the US. Think of this as the first domino, not the outcome.

Independent primary care, whole person.

AchillesAnnaPortland, OR7 points10d ago
Finally, some real human data coming.

Slow is smooth. Smooth is 5k pace eventually.

jumpers_knee_jessOmaha, NE3 points10d ago
What's the injury population, tendon specific or general?

Isometrics before ice. Every time.

LabRatLouisBoston, MA3 points10d ago
Nobody's posted the actual protocol details publicly yet as far as I can find, just that it's tissue healing broadly. I'd want to know injury type, injection frequency, duration, and whether they're doing imaging or just patient reported outcomes before I get excited about the design. Plenty of RCTs get registered and never finish enrollment.

Preclinical is not a promise.

slow_healer_samBoise, ID6 points10d ago
Hoping this means better access eventually, been chasing this stuff for two years now.

Still here. Still slow.

CoachTerrellAtlanta, GA5 points10d ago
Access won't fix your loading program though.

You cannot inject your way out of a bad program.

PharmD_NadiaPhoenix, AZ1 points10d ago
From the pharmacy side, the compounding restrictions are the real bottleneck right now, not lack of research interest. A trial doesn't change scheduling status.

If the vial looks cloudy, the answer is no.

Mod_HelenMadison, WI3 points10d ago
Good thread. Reminder we're discussing the trial's existence and design here, not sourcing questions, keep it in this lane and we're fine.

Read the pinned rules. They are short.