posted by BSearls_Coach 10d ago

Can I take them orally or do they have to be injected?

Client of mine just had a lisfranc reconstruction and asked me about oral BPC-157 instead of pinning because she's needle phobic. I only ever injected during my own rehab years back and never looked into the capsule versions people sell online. Does oral actually do anything for tendon and ligament healing or is that more of a gut thing? Want to give her real info before she wastes money on the wrong route.

Been through rehab myself. It works if you work it.

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GKatz_ATCMid-Atlantic region6 points10d ago

From the return to play side, everything I've seen clinically points toward injectable for musculoskeletal work. BPC-157 was isolated from gastric juice originally, so oral seems to concentrate in the gut more than anywhere else. For a lisfranc repair I'd push her toward sub-q if she can get past the needle thing.

Twenty plus years keeping athletes on the ice.

ELee_DPTMaryland, Washington D.C. metro area5 points10d ago

Oral for tendons is basically a waste of cash mate.

Lost my career to a knee. Now I fix them.

NOuta_ResearchKenya6 points9d ago

Anyone got real numbers on oral bioavailability beyond that 10 to 30 percent estimate floating around?

Science is only useful if people can use it.

MDrake_DPTBaltimore, Maryland3 points9d ago

The stomach acid stability is what makes BPC-157 unique among peptides, oral actually survives digestion which is why it gets used for GI stuff in the first place. But that stability doesn't mean it's getting where you want it for tendon or ligament repair. Sub-q injection hits systemic circulation within about 15 to 30 minutes, and the animal data that everyone cites for orthopedic healing used injectable routes, not oral. Nobody has published tissue level data on oral dosing so you're guessing on penetration past the gut. For a lisfranc I'd tell her injectable is the informed choice, not the easy one.

Neuro rehab nerd, clinical educator.

BSearls_CoachOrlando, Florida7 points9d ago

Worth combining oral and injectable or is that overkill?

Been through rehab myself. It works if you work it.

BCole_FSTHouston, Texas4 points9d ago

I've paired sub-q BPC-157 with fascial stretch work post op a few times and the tendon glide comes back noticeably faster, not saying it's the peptide doing it alone but the combo has looked better than either thing solo in my clients.

Move well first. Everything else follows.

ELee_DPTMaryland, Washington D.C. metro area5 points9d ago

Stick to injectable for the lisfranc, don't overthink it.

Lost my career to a knee. Now I fix them.

LBenz_PTLouisville, Kentucky1 points8d ago

Pick the route that matches the tissue you're targeting, not the one that's easiest to swallow.

Humanize the rehab process.

GKatz_ATCMid-Atlantic region4 points8d ago

If she ever stacks with TB-500 down the road that one's injectable only, no oral version has any real backing behind it. Might as well get her comfortable with pinning now while she's already motivated.

Twenty plus years keeping athletes on the ice.

BSearls_CoachOrlando, Florida3 points8d ago

Since we're on delivery methods, anyone using GHK-Cu topically on incision scars once healed? Curious on timing.

Been through rehab myself. It works if you work it.

NOuta_ResearchKenya3 points8d ago

Topical GHK-Cu has decades of human data behind it, way more than the injectable route ever will.

Science is only useful if people can use it.

MDrake_DPTBaltimore, Maryland6 points8d ago

Wait until the incision is fully closed and cleared by her surgeon, then topical is solid for scar quality.

Neuro rehab nerd, clinical educator.

BCole_FSTHouston, Texas3 points8d ago

Scar tissue looks better every time I've seen clients use it right.

Move well first. Everything else follows.

BSearls_CoachOrlando, Florida1 points7d ago

This helps a ton, going sub-q for her and holding off oral for now. Appreciate it.

Been through rehab myself. It works if you work it.

ELee_DPTMaryland, Washington D.C. metro area5 points7d ago

Good call, she'll thank you later.

Lost my career to a knee. Now I fix them.